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Differential Proteome Mapping of Resting and Activated Mouse CD8 T-Cells

presented by

Kenway Hoey
R.W. Johnson Pharmaceutical Research Institute

January 08, 1998

The Scripps Research Institute, W.M. Keck Foundation Amphitheater


Background:

With a degree in Chemistry from the University of California, San Diego, Kenway Hoey has been doing work in protein and peptide analysis for twenty five years. From 1972-1982 Kenway was at the Hormone Research Laboratory at the University of California, San Francisco. He has since been doing research at R.W. Johnson in their Protein-Peptide Chemistry Lab, fulfilling both scientific and managerial demands. He is currently a Senior Scientist in the Peptide Chemistry Lab at R.W. Johnson in San Diego.

Abstract:

Much effort has been spent by pharm-aceutical companies in the area of genomics analysis. However, no drug candidates have yet been identified. Besides the complementary genomic approach, proteome mapping is also a very powerful technique for iden-tifying drug targets. Using different paradigms, one can study differences in protein expression. After MS-MS analysis of enzymatically digested spots from a 2D gel, peptide sequences are generated and correlation analysis against public databases are completed. After comparing these protein sequences against our proprietary DNA/protein database, we can then identify new drug targets. Progress in our proteomics program will be reviewed in the presentation.

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