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Recent Advances in the Analysis of Oligosaccharides Using MALDIFourier Transform Mass Spectrometry

presented by

Mark Cancilla
University of California, Davis

January 08, 1998

The Scripps Research Institute, W.M. Keck Foundation Amphitheater


Background:

Mark Cancilla received his B.S. in Chemistry from Cal Poly San Luis Obispo, after which he worked as a quality control analytical chemist at Alza Pharamceuticals. He is currently working with Dr. Carlito Lebrilla at the University of California, Davis and will be obtaining his Ph.D. in Analytical Chemistry in June of 1998.A major component of Mark's research involves the development of new Fourier transform mass spectrometric apparatuses and techniques for the analyses of biomolecules, namely oligosaccharides. He has studied the fundamental gas phase chemistry of oligosaccharide ions which has led to the greater understanding of their dissociation pathways and has ultimately led to new carbohydrate sequencing techniques using mass spectrometry.

Abstract:

New techniques for analyzing and sequencing oligosaccharides using MALDI-FTMS will be presented by Mark Cancilla at the upcoming SANDMAN meeting. Topics will include the application of CID to elucidate unknown oligosaccharides and a new technique which unambiguously determines the full sequence and linkage information for oligo-saccharides by analyzing the alkaline degradation products by MALDI-FTMS. A third topic will be the use of sulfate as a novel dopant to form anionic quasimolecular ions and in situ derivatives of neutral oligosaccharides from MALDI.

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