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Ion Trap Mass Spectrometry

presented by

R. Graham Cooks
Purdue University

January 06, 1999

The Scripps Research Institute, W.M. Keck Foundation Amphitheater


Background:

R. Graham Cooks has been making significant contributions to mass spectrometry for the past thirty years. After obtaining a Ph.D. from the University of Natal in South Africa, he went to Cambridge in Great Britain for further doctoral and post-doctoral study, finishing there in 1968. He then spent several years as an Assistant Professor in the Chemistry Dept. at Kansas State University. Over the next 15 years he served as the Co-Director and later Director of the Mass Spectrometry Center at Purdue, as well as a Chemistry faculty member. Prof. Cooks was named a Fulbright Senior Fellow of the University of Warwick in 1981 and an Adjunct Professor at Beijing Institute of Technology in 1987. In 1990 he was named a Henry Bohn Hass Distinguished Professor of Chemistry at Purdue University where he continues today.R.G. Cooks has been recognized both nationally and internationally for his service to mass spectrometry, having received research awards for chemical instrumentation, tandem mass spectrometry and analytical chemistry. Moreover, he serves on a number of editorial boards, has advised 65 Ph.D. students over the years, and has well over 500 publications.Several new types of mass spectrometers have been constructed in Professor Cooks' laboratory, including hybrid sector/quadrupole instruments and advanced ion trap instruments capable of MS/MS experiments. His group made significant contributions to the development of desorption ionization and tandem mass spectrometry as methods of analysis of complex mixtures. His work on the kinetic method of measuring thermochemical quantities is one outcome of his interest in ion structure and fragmentation mechanism.

Abstract:

This talk surveys the applications and details the fundamentals of mass spectrometry as carried out using the quadrupole ion trap. A general introduction to mass analyzers and ionization methods is followed by a survey of ion trap capabilities and applications. The fundamentals of ion motion in the ion trap are explored using computer simulations and experiments. Thermochemical determinations and scans that are specific for functional groups are treated. Simulation is used to guide new experiments. Frontier topics include high resolution, chemical shifts, ion mobility, and ion thermochemistry. New miniature ion traps are described, as are experiments aimed at producing arrays of ion traps.

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