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Ligand induced stabilization of nuclear receptors - use of hydrogen deuterium exchange mass spectrometry to assist design selective modulators

presented by

Patrick R. Griffin
ExSAR

December 18, 2003

The Scripps Research Institute, ICND Auditorium


Background:

Dr. Griffin is currently CSO of ExSAR. Prior, he was Senior Director, Basic Chemistry, at Merck and spent 11 years applying technology to discovery phase DMPK and molecular profiling (proteomics) in many drug programs including several NHR programs such as PPARalpha, PPARy, GR LXR, FXR and SERMS. Dr. Griffin was a key contributor to the discovery and development of DMP-777 (Phase IIb), a human leukocyte elastase inhibitor.

Abstract:

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