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Time-dependent Protein Stability Examined by Mass Spectrometry

presented by

Edward Luedke
Amgen, Inc.

June 26, 1995

The Scripps Research Institute, The Committee Lecture Hall


Background:

Ed obtained his Ph.D. in Pharmacology at the University of California at Santa Barbara before heading east to work as a post-doctoral fellow at Merck Research Laboratories in Rahway, New Jersey. Dr. Luedke's work in their Department of Immunology and Inflammation concentrated on the purification and characterization of proteinases from humans and monkeys which were thought to be involved in the tissue damage that occurs during chronic inflammatory diseases such as emphysema and other COPD. Following his post-doctoral work, Dr. Luedke left the Garden State and returned to California to a position as a research scientist at Amgen, Inc. in Thousand Oaks. He has continued there as a member of the Department of Analytical Research and Development and is currently applying mass spectrometry to the characterization of recombinant protein therapeutics, including degradation pathways, the determination of stability limiting reactions, and post-translational modifications.

Abstract:

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