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Separation Science and Mass Spectrometry in the Service of Glycomics, Proteomics and Metabolic Profiling

presented by

Milos V. Novotny
University of Georgia

November 08, 2004

GNF Auditorium,
10675 John Jay Hopkins Drive, La Jolla, CA


Background:

Professor Milos Novotny, who directs IU Bloomington's Institute for Pheromone Research, has long been involved with developing new high-resolution and ultra-sensitive bioanalytical separation techniques. His research focus on the identification of sparse, low-density substances by developing devices and techniques that substantially improve the resolution of complex biological mixtures and identification of the separated compounds.

Abstract:

The vast complexity of biological mixtures necessitates sophisticated tools to resolve, identify and measure quantitatively their individual components (molecular entities). From a historical perspective, this was realized for the first time during the late 1960s when the term ?metabolic profiles? was coined, but when the available mythologies lacked sufficient versatility to cover the entire range of biological molecules. 2-D electrophoresis and capillary separation techniques during the following decades added significantly to the scope of investigations of biomolecules, small and large. When biomolecular mass spectrometry was added to the arsenal of available techniques for molecular identification, the gate was opened to today?s holistic practice of genomics, proteomics and all other ?-omics?. Importantly, all these powerful bioanalytical methodologies still continue to develop and be utilized for acquisition of highly complex quantitative data that may reveal the secrets and intricacies of living processes. The lecture will emphasize the recent developments in functional glycomics, glycoproteomics and quantitative metabolic profiling.

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