and Mass Spectrometry

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Analysis of Combinatorial Libraries Using Laser Desorption Time-of-Flight Mass Spectrometry

presented by

Sylvie Blondelle
Torrey Pines Institute for Molecular Sciences

June 26, 1995


After growing up in Northern France and receiving her Bachelor of Science degree in both Physics and Mathematics, Sylvie Blondelle headed south. She conducted her doctoral studies at the University of Montpellier in Southern France, obtaining her Ph.D. in Organic Chemistry in 1988 with emphasis in Peptide Chemistry. Having spent this time in the mild Mediterranean climate, Dr. Blondelle felt right at home when she arrived in La Jolla to work as a postdoctoral research fellow at the Scripps Clinic and Research Foundation. Here Dr. Blondelle worked in Dr. Richard Houghton's lab performing studies on antimicrobial peptides, and joined him when he created the Torrey Pines Institute for Molecular Studies (TPIMS) in 1989. Dr. Blondelle has been at the Institute ever since, except for a 10 month return to France where she worked at the University Louis Pasteur in Strasbourg, near the German border. Under a contract from the CNRS (National Center for Scientific Research), her work here was directed toward the development of antimicrobial assays for the isolation and characterization of novel antimicrobial compounds from insect extracts. Preferring the dynamic scientific community of San Diego, Dr. Blondelle returned to TPIMS as an Assistant Member and as the Principal Investigator of a group directed toward the understanding of structure-activity relationships of peptides and proteins.As a part of TPIMS since its inception, Dr. Blondelle has a broad background in all their research on the synthesis, analysis, and use of combinatorial libraries. Her contribution is more oriented toward the use of combinatorial libraries to identify new compounds having antimicrobial and/ or antifungal activities, compounds having enzyme inhibitory activities, or modulatory activities on cytolytic or regulatory proteins, and compounds having catalytic-like activities. Dr. Blondelle has used mass spectrometry, specifically laser desorption time -of -flight spectrometry, to characterize individual peptides which are synthesized at the Institute. Morerecently, she has employed mass spec as a tool to analyze the overall identity of peptide combinatorial libraries, as well as to monitor chemical transformations carried out on the peptide bonds.


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