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Metabolomics and Metabolomic Profiling Concepts and Applications

presented by

John Shockcor
Waters Corporation

November 17, 2005

The Scripps Research Institute, W.M. Keck Foundation Amphitheater


Background:

Dr. Shockcor is a Fellow of the Royal Society of Chemistry with over 30 years of experience in analytical chemistry using NMR spectroscopy and mass spectrometry. He received his BSc from Cleveland State University and his PhD from Imperial College London. He has been involved in metabolic profiling studies for the past 25 years and has extensive experience in metabonomics. He is a founding Member of the ?Consortium for Metabonomic Toxicology? (COMET) and is Author/co-author of 80 publications and 106 presentations on various aspects of NMR, mass spectrometry, metabonomics and their application in the pharmaceutical industry.

Abstract:

From the post genomics and proteomics era, metabonomics has emerged as a vital new area of research. Metabolic profiles of biological fluids contain a vast array of endogenous low-molecular weight metabolites, the composition of which depends upon the sample type (plasma urine, bile etc) and factors such as the species, age, sex, diet of the organism from which the sample derives and indeed even the time of day at which the sample was taken.


Metabonomics uses data from information rich analytical techniques, in particular, MS and/or NMR, which provide spectral patterns that can be evaluated using statistical methods, such as principal component analysis (PCA), to highlight both subtle and gross systematic differences between samples. Evaluation of these observed biochemical changes over time can provide critical information on the mechanism of the perturbation.


In this talk, Dr. Shockcor will present data to illustrate these concepts and demonstrate the application of both metabonomics and metabolic profiling studies to drug discovery and development.

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